- Department / Institute
- Institute for Stroke and Dementia Research
- Subject area
- Cardiovascular research, stroke research, inflammation research
- Name of Supervisor
- Professor Dr. rer. nat. Jürgen Bernhagen
- Number of open positions
- 1
- Project titles
- 1. MIF-family proteins in ischemic stroke
- Language requirements
- English
- Academic requirements
- Master in Biological Sciences, i.e. Molecular Biology, Biochemistry, Cell Biology, Medical Chemistry, Molecular Biotechnology or similar
or Master in Medicine with speciality in Cardiology, Neurology, or Immune and Inflammatory Diseases - Contact
- csc.international@lmu.de
Project description
MIF-family proteins in ischemic stroke
MIF proteins are inflammatory cytokines with chemokine-like activities that play a well-described pivotal role in the pathogenesis of atherosclerosis, other cardiovascular conditions, and various inflammatory diseases. Initial reports have suggested that MIF (MIF-1) plays a causal role in ischemic stroke, but the underlying mechanism and the role of novel MIF family members and the interplay with the MIF receptors in unclear. Interestingly, intracellular activities of MIF have recently been implied and sex-specific effects have been observed. We will unravel the mechanism behind these observations and characterize the role of MIF proteins and their receptors in their entirety in ischemic stroke. The thesis will be inherently embedded into this task and cover a substantial part of these project aims.