Postdoc in dendritic cell biology/ age-dependent immune regulation (m/f/x)

Institution
Faculty of Biology - Biomedical center, Walter Brendel Center
Start date
as soon as possible
Application deadline
5 Jun 2022
Remuneration group
TV-L

Our group at the Biomedical center, LMU Munich, Germany is looking for a motivated postdoc with a strong background in immunology or cell/molecular biology and an interest in innate immunity.

Dendritic cells are versatile controllers of the immune system that sense pathogens and damage to initiate the bodies defense. We study how the development and function of these cells are shaped by environmental factors. The neonatal period in mammals represents a critical window, in which the immune system has to balance efficient pathogen defense with maintaining tolerance against commensal microbes and environmental antigens. Dendritic cells in neonates are qualitatively distinct from those in adults and in early life have therefore often been considered underdeveloped or functionally immature. In contrast to this dogma, we have found that despite exhibiting age-dependent differences in cell function some dendritic cell subtypes in early life are fully competent to induce T cell responses (Papaioannou et al, NComms, 2021).

Tasks and responsibilities

The advertised position will employ transgenic mouse models to fate map and specifically manipulate gene expression in dendritic cells in steady state and inflammation. Single cell technologies (transcriptomics and flow cytometry) will be coupled to functional assays in vitro and in vivo to understand the molecular mechanisms underlying the age-dependent functional regulation of dendritic cells. More information find here.

Requirements

  • Commitment and initiative in a dynamic and international research environment
  • Expertise in the above-mentioned techniques
  • Proficiency English is required, proficiency in German is a plus
  • Doctoral degree in Immunology, Cell Biology, Biomedicine, Physiology, Bioinformatics or the like.

Benefits

  • An enthusiastic international team
  • A diverse range of tasks associated with a high degree of responsibility
  • Opportunity to teach and possibility of “Habilitation” at LMU Munich
  • Offers to support compatibility of family and work
  • Full-time position available immediately, salary based on German public service scale (TV-L).

Also possible in a part-time capacity.

People with disabilities who are equally as qualified as other applicants will receive preferential treatment.

Contact

Enquiries and applications directly to Dr. Barbara Schraml. Quote: PD23. Please include merged in a single pdf file: a short statement of research interests and why you chose to apply for this position, CV, list of publications, as well as names and contact information of three references.

Call closes 05.06.2022.

Email: barbara.schraml@bmc.med.lmu.de

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