Experimental Cell Therapy (Wichmann)

Department / Institute
Division of Transfusion Medicine, Cell Therapeutics, and Hemostaseology, University Hospital of the LMU Munich
Subject area
Experimental Cell Therapy
Project title
Development of improved lentiviral CAR-T vectors for cell therapy
Name of supervisor
PD Dr. med. Christian Wichmann
Number of open positions
Language requirements
Proficiency in English
Academic requirements
Master's Degree
Project time plan
Full Doctoral Study-Model: 36 or 48 months

Project description

The adoptive cell transfer of antigen-receptor-modified T-lymphocytes/T-cells (Car-T-cells) is a new component of cancer immunotherapy. The patient's own (autologous) T-lymphocytes are obtained by apheresis. They are then provided with a viral vector (a so-called gene shuttle) with the help of which a gene (the CAR) is introduced into the T cells. This gene recognizes a specific cell surface antigen, e.g. B. CD19 on malignant B cells, and induces cell death of the CD19-positive tumor cells. In addition to the desired anti-tumor effect, however, the procedure has some very dangerous side effects such as uncontrolled cytokine release. New, controllable vectors are intended to make these side effects manageable.

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