Vascular Research (Bernhagen/Hoffmann 2) 

Department / Institute
Department for Vascular Biology, Institute for Stroke and Dementia Research
Subject area
Inflammation Research, ARDS Research, Vascular Research
Name of supervisor
Prof. Dr. Jürgen Bernhagen, Dr. Adrian Hoffmann
Number of open positions
Project title
Function of MIF proteins at the crossroad of innate and adaptive immune responses: focus on dendritic and T cell interplay
Language requirements
Fluency in English
Academic requirements
4-year Bachelor's plus Master's degree
Study model
Full doctoral study model: 36 or 48 months
Prof. Dr. Jürgen Bernhagen:
Dr. Adrian Hoffmann:

Project description

This project focuses on the functions of MIF proteins on dendritic cells and T cells. MIF is considered to be an innate cytokine/chemokine which exerts most of its roles by controlling cells of the innate arm of the immune system. However, recent evidence also suggests a critical role for MIF and its homolog MIF-2 in the control of T-cell activity. In the project, these novel unexpected effects will be studied via well-established basic immunological techniques as well as innovative and technologically advanced functional leucocyte assays. Systematic comparison of MIF, MIF-2, and their receptors will lead to an in-depth mechanistic exploration of the currently unknown MIF-family induced interplay of dendritic cells and T cells at the crossroad of the innate and adaptive immune responses. This is of particular interest, as a dysbalance in the alveolar immune milieu, e.g. dysregulated interplay between pro- versus anti-inflammatory mediators and T regulatory versus Th17 cells, plays a decisive role in the pathophysiological processes in ARDS.

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