Vascular Surgery (Tsilimparis 4) 

Department / Institute
Department for Vascular Surgery
Subject area
Aorta, Endovascular Aortic surgery
Name of supervisor
Prof. Dr. Nikolaos Tsilimparis, Jan Stana PhD
Number of open positions
Project title
"In vitro" evaluation of the degree of optimal oversizing of aortic stent-grafts in bovine aorta in aortic procedures
Language requirements
Fluency in English
Academic requirements
4-year Bachelor's plus Master's degree; preferably clinical experience in vascular surgery
Study model
Full doctoral study model: 36 months

Project description

Study rationale: The optimal oversizing percentage of endografts for treatment of aortic pathologies is unknown, with recommendations ranging from 0-30% depending on the type of pathology, stentgraft design, and physician preference. This is becoming increasingly interesting in proximal landing zones in the ascending aorta, after previous open repair.

Study objectives: The aim of this study was to create an "in-vitro" model for mechanical testing of different percentages of oversizing, and subsequently, to determine the optimal oversizing percentage of aortic endografts deployed in bovine graft landing areas.

Study design and plan:

  • Experimental “in vitro” study
  • Objective: “in vitro” evaluation of the optimal percentage of oversizing when landing an aortic stent in a bovine aorta.
  • Thoracic aortic endoprosthesis with different degrees of oversizing will be deployed inside on the bench in bovine aortas, observing the “in vitro” behavior according to the percentage of oversizing.
  • To simulate "real life" conditions, in a second, 3D models of different aortic anatomies will be made. A bovine aorta will be sutured on to the 3D models, followed by deployment of the aortic stent-grafts inside these allowing for conformability testing. In a third stage, flow analysis of these models will be performed.
  • Primary Endpoints: degree of complications of the proximal landing zone
    Endoleaks; Kinks; Infolding; Gutters
  • Secondary Endpoints: Conformability of the stent-grafts with the bovine aorta; physical/mechanical response of the bovine aorta to the degree of oversizing

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